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In February 2007, McKeith agreed to stop using the title "Doctor" in her advertising, following a complaint to the Advertising Standards Authority by a "Bad Science" reader.

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While investigating McKeith's membership of the American Association of Nutritional Consultants, Goldacre obtained a professional membership on behalf of his late cat, Henrietta, from the same institution for $60. He has been a particularly hardline critic of the nutritionist Gillian McKeith. Goldacre has criticised anti-immunisation campaigners (particularly followers of Andrew Wakefield such as Melanie Phillips and Jeni Barnett), Brain Gym, bogus positive MRSA swab stories in tabloid newspapers, publication bias, and the makers of the product Penta Water. Topics discussed included marketing, the media, quackery, problems with the pharmaceutical industry, and its relationship with medical journals. The column focused on pseudoscience and the misuse of science.

Goldacre was known for his weekly column, "Bad Science", which ran in the Saturday edition of The Guardian from 2003 until November 2011.

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In 2020, Goldacre was, with Liam Smeeth, the principal investigator of the OpenSAFELY collaboration which created a software platform to analyse the records of 24 million NHS patients to provide detailed risk factors for hospital deaths from COVID-19. Īs of 2016, according to Scopus and Google Scholar his most cited articles have been published in NeuroReport, the European Journal of Preventive Cardiology, the British Medical Journal, The Lancet, and PLOS ONE. In 2022, he became the first Bennett Professor of Evidence-Based Medicine and director of Oxford's newly-established Bennett Institute for Applied Data Science.

In 2015, Goldacre moved to the Nuffield Department of Primary Care Health Sciences's Centre for Evidence-Based Medicine at the University of Oxford, joining a project funded by a grant from the Laura and John Arnold Foundation. In 2012, Goldacre was appointed a Wellcome Trust Research Fellow in Epidemiology at the London School of Hygiene & Tropical Medicine. He was made a research fellow at the Institute of Psychiatry in London in 2008, and a Guardian research fellow at Nuffield College, Oxford, in 2009. Goldacre passed the Member of the Royal College of Psychiatrists (MRCPsych) Part II examinations in December 2005 and became a member of the Royal College of Psychiatrists. He also received a Master of Arts degree in philosophy from King's College London in 1997. Following his studies at the Universities of Oxford and Milan, Goldacre studied clinical medicine at UCL Medical School, qualifying as a medical doctor in 2000 with a Bachelor of Medicine, Bachelor of Surgery (MB, BS) degree. Goldacre was a visiting researcher in cognitive neuroscience at the University of Milan, working on fMRI brain scans of language and executive function. He edited the Oxford student magazine, Isis. He studied medicine at Magdalen College, Oxford, where he obtained a first-class Bachelor of Arts honours degree during his preclinical studies in 1995 in Physiological Sciences. Goldacre was educated at Magdalen College School, Oxford. He is the nephew of Robyn Williams, a science journalist, and the great-great-grandson of Henry Parkes, politician and journalist who is considered the father of the Australian Federation. Goldacre is the son of Michael Goldacre, a professor of public health at the University of Oxford, and Susan Traynor (stage name Noosha Fox) lead singer of 1970s pop band Fox, both of whom are Australian.

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Goldacre frequently delivers free talks about bad science he describes himself as a "nerd evangelist". Goldacre is known in particular for his Bad Science column in The Guardian, which he wrote between 20, and is the author of four books: Bad Science (2008), a critique of irrationality and certain forms of alternative medicine Bad Pharma (2012), an examination of the pharmaceutical industry, its publishing and marketing practices, and its relationship with the medical profession I Think You'll Find It's a Bit More Complicated Than That, a collection of his journalism and Statins, about evidence-based medicine. He is a founder of the AllTrials campaign and OpenTrials to require open science practices in clinical trials. He is the first Bennett Professor of Evidence-Based Medicine and director of the Bennett Institute for Applied Data Science at the University of Oxford.